Changde Yungang Biotechnology Co., Ltd
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Tel: +86-736-7391178
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City: Changde
Street: Qiaonan Industrial Park, Changde City, Hunan Province
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CAS NO.81-25-4
Offer 81-25-4 98.0% global trader
| Product name | Cholic acid |
| CAS number | 81-25-4 |
| MF | C24H40O5 |
| Acidity coefficient (pKa) | 4.98(at 20℃) |
| condition of storage | Store at RT. |
| solubility | methanol: 0.1 g/mL, clear |
| Flash point |
9℃ |
Description
Cholic acid, also known as 3α,7α,12α-trihydroxy-5β-cholan-24-oic acid is a primary bile acid that is insoluble in water (soluble in alcohol and acetic acid), it is a white crystalline substance. Salts of cholic acid are called cholates. Cholic acid, along with chenodeoxycholic acid, is one of the two major bile acids produced by the liver, where it is synthesized from cholesterol. These two major bile acids are roughly equal in concentration in humans. Derivatives are made from cholyl-CoA, which exchanges its CoA with either glycine, or taurine, yielding glycocholic and taurocholic acid, respectively.
Cholic acid downregulates cholesterol-7-α-hydroxylase (rate-limiting step in bile acid synthesis), and cholesterol does the opposite. This is why chenodeoxycholic acid, and not cholic acid, can be used to treat gallstones (because decreasing bile acid synthesis would supersaturate the stones even more).
Cholic acid and chenodeoxycholic acid are the most important human bile acids. Other species may synthesize different bile acids as their predominant primary bile acids.
Cholic acid, formulated as Cholbam capsules, is approved by the United States Food and Drug Administration as a treatment for children and adults with bile acid synthesis disorders due to single enzyme defects, and for peroxisomal disorders (such as Zellweger syndrome).
Offer 81-25-4 98.0% global trader
| Cholic acid Chemical Properties |
| Melting point | 200-201 °C(lit.) |
| alpha | 36 º (c=0.6, 95% EtOH) |
| Boiling point | 449.08°C (rough estimate) |
| density | 1.0310 (rough estimate) |
| refractive index | 1.5800 (estimate) |
| Fp | 9℃ |
| storage temp. | Store at RT. |
| solubility | methanol: 0.1 g/mL, clear |
| pka | 4.98(at 20℃) |
| Water Solubility | 0.28 g/L (15 ºC) |
| Merck | 14,2203 |
| BRN | 2822009 |
| CAS DataBase Reference | 81-25-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Cholic acid(81-25-4) |
| EPA Substance Registry System | Cholan-24-oic acid, 3,7,12-trihydroxy-, (3.alpha.,5.beta.,7.alpha., 12.alpha.)-(81-25-4) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 24/25-36-26 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 2 |
| RTECS | FZ9350000 |
| TSCA | Yes |
| Hazardous Substances Data | 81-25-4(Hazardous Substances Data) |
| MSDS Information |
| Provider | Language |
|---|---|
| 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid | English |
| ACROS | English |
| SigmaAldrich | English |
| ALFA | English |
Changde Yungang Biotechnology Co., Ltd. is an export-oriented hi-tech enterprise; we are mainly engaged in the research, development, manufacturing and trade of pharmaceutical intermediates. Staring from the innovations of technology and product, Yungang is striving to develop new products and technologies; we are working hard for promoting its competitive force and sustainable developing capacity. Led by Deng Jiaguo (the founder and general manager of Yungang), we adopt the latest technologies to produce Ursodeoxycholic acid and chenodeoxycholic acid serial products. The preparation method of chenodeoxycholic acid has passed the authentication of technical achievement of our province and got several Chinese patents. At present, our Ursodeoxycholic acid can meet the standards of CP, USP and JP; Meanwhile, we also offer other specifications of products to customers with special requirements. Now, our main products including Ursodeoxycholic acid, chenodeoxycholic acid, Hyodeoxycholic acid, Cholic acid, Deoxycholic acid, Dehydrocholic acid and bacteria quarantine series such as bile salts of cow, bile salts 3, bile salts of fowl, cattle goll powder, bile powder of pig, deoxidization sodium cholate, and so on. Relying on the excellent strength of Chinese hi-tech enterprise and upholding such idea and culture spirit of "Honest, Unity, Be practical, be enterprising, be creative", we are working for customers' demands. Yungang looks forward to cooperating with you.