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Supply Cholic Acid 81-25-4 for sale Cholic Acid with low price
Properties
Appearance & Physical State: white to off-white crystalline powder
Density: 1.184g/cm3
Melting Point: 197-202ºC
Boiling Point: 545ºC
Flash Point: 321ºC
Refractive Index: 1.558
Water Solubility: 0.28 g/L (15 ºC)
Stability: Stable under normal temperatures and pressures.
Storage Condition: Store at RT.
Application
(1) It can emulsify fat and improve its function of digestion as a kind of organic acid.
(2) It can be applied in emulgator.
(3) It can be applied in the research of biochemistry as a kind of medical intermediate.
(4) It can be applied in non ion-modified detergent to extract membrane protein.
(5) It is mainly used as medicine raw materials.
(6) The cholesterol is still the raw material of cosmetics, and a good surfactant of medicine products. It can also be used for additive of animal feed.
Function
(1) It can treat cholecystitis, the lack of bile, intestinal indigestion and gallstones etc.
(2) It can prevent and treat liver diseases.
(3) It is a kind of organic acid and can be used to produce vitamin D2 and D3.
NAME: Cholic Acid HPLC≥ 98.0% CHEMICAL NAME: 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid FORMULA :C24H40O5 MOLECULAR WEIGHT : 408.58 CAS …
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Safety Info
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Symbol: |
GHS07 |
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Sign: |
Warning |
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hazard declaration: |
H315; H319 |
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hazard declaration add: |
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waring notice: |
P305 + P351 + P338 |
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RTECS: |
FZ9350000 |
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Safety Statements: |
S24/25 |
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HS Code: |
2942000000 |
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WGK Germany: |
2 |
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Risk Statements: |
R36/37/38 |
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Hazard Codes: |
Xi |
Details
NAME: Cholic Acid HPLC≥ 98.0% CHEMICAL NAME: 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid FORMULA :C24H40O5 MOLECULAR WEIGHT : 408.58 CAS NUMBER: 81-25-4
2. Ethyl acetate separation method
Preparation of crude hyocholic acid: Add 3-3.5 times of saturated lime supernatant into fresh pig bile under stirring, then continue to stir it for 5-10min. heating to boiling for 2min, cooling, through filtration, adding hydrochloric acid to PH3.5 to get precipitation, standing for more than 12h can obtain crude acid. Removing, washing, adding 1.5 times the sodium hydroxide, plus 9 times the water, heating and boiling 12-18h, cooling, standing overnight obtain paste. Add water and sulfuric acid to pH 1 to precipitate pig cholic acid. Removing, crushing, rinsing to no acidity, through filtration gains crude pig cholic acid.
[pig bile] [saturated limewater] →[100℃, pH 11-12] Basic filtrate [HCl] → [pH3.5] Crude cholic acid [water, NaOH] → paste [H2SO4] → [pH1] crude pig cholic acid
Preparation of pig cholic acid products: add 4 times the amount of ethyl acetate to the crude pig cholic acid. Add 150-200g/L activated carbon; heat and flux for 0.5h; cool; filter; add 1.5-2.5 times ethyl acetate to filter cake; combine the filtrates twice. Adding 200g/L anhydrous sodium sulfate, standing overnight, concentrated to the original volume of 1/3, releasing, cooling crystallization, through filtration, washing with ethyl acetate crystallization, drying can obtain pig cholic acid products.
Crude pig cholic acid [ethyl acetate, activated carbon] → filtrate [anhydrous sodium sulfate] → filtrate [concentration] → pig cholic acid products.
Chemical Properties white to light beige crystalline powder
Uses Choleretic produced by, and isolated from liver cells.
Uses asthma therapeutic
Uses Cholic Acid is an emulsifier that exists as colorless plates or a white crystalline powder which has a bitter taste with a sweetish aftertaste. it is slightly soluble in water. it functions as an emulsifying agent in egg white.
Definition ChEBI: A bile acid that is 5beta-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12.
Purification Methods This bile acid crystallises from H2O or wet Et2O (as hydrate) or EtOH (as alcoholate). Dry it under vacuum at 94o. When an alcoholic solution of cholic acid + I2 is added to aqueous KI, it forms a molecular compound (C24H40O5I)4 KI. H2O. The methyl ester is dimorphic with m 155o and 162o and [] D 20 +25o (EtOH). [Anderson et al. Biochem J 67 323 1957, 85 236 1962, Beilstein 10 III 2162, IV 2071.]
China (Mainland)
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