Superiority
The factory 474-25-9 taste bitter Chenodeoxycholic Acid with unusual stink
Quick Details
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CAS No.:
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474-25-9
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Other Names:
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Chenodeoxycholic acid powder
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MF:
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C24H40O4
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EINECS No.:
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N/M
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Place of Origin:
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Shaanxi, China (Mainland)
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Type:
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Auxiliaries and Other Medicinal Chemicals, Immune Function Agents, Vitamins, Amino Acids and Coenzymes
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Grade Standard:
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Medicine Grade, Tech Grade
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Usage:
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Animal Pharmaceuticals
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Brand Name:
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KONO
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Model Number:
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KONO3
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Purity:
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99%, 99%
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Product Name:
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Chendeoxycholic acid
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Source:
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bile
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Appearance:
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white powder
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Assay by:
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HPLC
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Mesh size:
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100% pass 80 mesh
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Standard:
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In house,FCC, USP/NF, JECFA, EP, GBIT
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Shelf life:
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2 years when properly stored
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Functions:
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for supplements and pharmaceuticals
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Package:
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drum and foil bag,or required by clients
HPLC≥98.0% 474-25-9 supplier Chenodeoxycholic Acid HPLC≥95.0%
We are the earliest factory for extraction of cdca from porcine gallbladder. Our company mainly from pig gallbladder and poultry gallbladder, extraction of pig gallbladder technology is an international initiative, it is the core technology of our company.
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Chenodeoxycholic acid Basic information |
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Product Name: |
Chenodeoxycholic acid |
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Synonyms: |
URSODEOXYCHOLOC ACID;3,7-dihydroxy-,(3-alpha,5-beta,7-alpha)-cholan-24-oicaci;3,7-dihydroxy-,(3alpha,5beta,7alpha)-cholan-24-oicaci;3,7-Dihydroxy-5-Cholanicacid;3-alpha,7-alpha-dihydroxy-5-beta-cholan-24-oicaci;3-alpha,7-alpha-dihydroxy-5-beta-cholan-24-oicacid;3-alpha,7-alpha-dihydroxycholanicacid;3-alpha,7-alpha-dihydroxycholansaeure |
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CAS: |
474-25-9 |
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MF: |
C24H40O4 |
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MW: |
392.57 |
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EINECS: |
207-481-8 |
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Product Categories: |
Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Intracellular receptor |
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Mol File: |
474-25-9.mol |
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Description
Chenodeoxycholic Acid CAS NO.:474-25-9
Source: extracted from poultry bile
Quality standard：HPLC≥98.0% ；HPLC≥95.0% ；HPLC≥90.0%
Effect and use: with anti-inflammatory, cough, expectorant, dissolution of stones and so on.
Chenodeoxycholic acid (also known as chenodesoxycholic acid, chenocholic acid and 3α,7α-dihydroxy-5β-cholan-24-oic acid) is a bile acid. It occurs as a white crystalline substance insoluble in water but soluble in alcohol and acetic acid, with melting point at 165-167°C. Salts of this carboxylic acid are called chenodeoxycholates. Chenodeoxycholic acid is one of the main bile acids produced by the liver.
It was first isolated from the bile of the domestic goose, which gives it the "cheno" portion of its name (Greek: χ?ν = goose).
Chenodeoxycholic acid and cholic acid are the two primary bile acids in humans. Some other mammals have muricholic acid or deoxycholic acid rather than chenodeoxycholic acid.
Chenodeoxycholic acid is synthesized in the liver from cholesterol by a process which involves several enzymatic steps. Like other bile acids, it can be conjugated in the liver with taurine or glycine, forming taurochenodeoxycholate or glycochenodeoxycholate. Conjugation results in a lower pKa. This means the conjugated bile acids are ionized at the usual pH in the intestine and will stay in the gastrointestinal tract until reaching the ileum where most will be reabsorbed. Bile acids form micelles which facilitate lipid digestion. After absorption, they are taken up by the liver and resecreted, so undergoing an enterohepatic circulation. Unabsorbed chenodeoxycholic acid can be metabolised by bacteria in the colon to form the secondary bile acid known as lithocholic acid.
Choendeoxycholic acid is the most potent natural bile acid at stimulating the nuclear bile acid receptor, farnesoid X receptor (FXR). The transcription of many genes is activated by FXR.
Participate in CPHI Exhibition：
Details
character Chenodeoxycholic acid
Parameter valueMelting point: 165-167 ° C (lit.)
Specific rotation of 12 ° C (C = 1, CHCl3)
Boiling point: 437.26 ° C (rough estimate)
Density: 0.9985 (rough estimate)
Refractive index: 1.4460 (estimate)
Flash point: 9 ℃
Storage condition
Solubility practically insoluble
Shape powder
Acidity coefficient (PKA) PKA 4.34 (uncertain)
White to off white
Water solubility
Merck 13,2062
BRN 3219887
InChIKey RUDATBOHQWOJDD-BSWAIDMHSA-N
CAS database 474-25-9 (CAS database reference)
EPA chemical information cholan-24-oic acid, 3,7-dihydroxy -, (3. Alpha., 5. Beta., 7. Alpha.) - (474-25-9)
China (Mainland)
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