Changde Yungang Biotechnology Co., Ltd
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CAS NO.474-25-9
crystallization powder 474-25-9 HPLC≥90.0% White or yellowish Chenodeoxycholic Acid
Quick Details
HPLC≥98.0% 474-25-9 supplier Chenodeoxycholic Acid HPLC≥95.0%
We are the earliest factory for extraction of cdca from porcine gallbladder. Our company mainly from pig gallbladder and poultry gallbladder, extraction of pig gallbladder technology is an international initiative, it is the core technology of our company.
| Chenodeoxycholic acid Basic information |
| Product Name: | Chenodeoxycholic acid |
| Synonyms: | URSODEOXYCHOLOC ACID;3,7-dihydroxy-,(3-alpha,5-beta,7-alpha)-cholan-24-oicaci;3,7-dihydroxy-,(3alpha,5beta,7alpha)-cholan-24-oicaci;3,7-Dihydroxy-5-Cholanicacid;3-alpha,7-alpha-dihydroxy-5-beta-cholan-24-oicaci;3-alpha,7-alpha-dihydroxy-5-beta-cholan-24-oicacid;3-alpha,7-alpha-dihydroxycholanicacid;3-alpha,7-alpha-dihydroxycholansaeure |
| CAS: | 474-25-9 |
| MF: | C24H40O4 |
| MW: | 392.57 |
| EINECS: | 207-481-8 |
| Product Categories: | Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Intracellular receptor |
| Mol File: | 474-25-9.mol |
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About us
Changde Yungang Biotechnology Co., Ltd. is an export-oriented hi-tech enterprise; we are mainly engaged in the research, development, manufacturing and trade of pharmaceutical intermediates. Staring from the innovations of technology and product, Yungang is striving to develop new products and technologies; we are working hard for promoting its competitive force and sustainable developing capacity. Led by Deng Jiaguo (the founder and general manager of Yungang), we adopt the latest technologies to produce Ursodeoxycholic acid and chenodeoxycholic acid serial products. The preparation method of chenodeoxycholic acid has passed the authentication of technical achievement of our province and got several Chinese patents. At present, our Ursodeoxycholic acid can meet the standards of CP, USP and JP; Meanwhile, we also offer other specifications of products to customers with special requirements. Now, our main products including Ursodeoxycholic acid, chenodeoxycholic acid, Hyodeoxycholic acid, Cholic acid, Deoxycholic acid, Dehydrocholic acid and bacteria quarantine series such as bile salts of cow, bile salts 3, bile salts of fowl, cattle goll powder, bile powder of pig, deoxidization sodium cholate, and so on. Relying on the excellent strength of Chinese hi-tech enterprise and upholding such idea and culture spirit of "Honest, Unity, Be practical, be enterprising, be creative", we are working for customers' demands. Yungang looks forward to cooperating with you.
Chemical Properties Off-White Solid
Uses Chenodeoxycholic acid is a bile acid that induces apoptosis through protein kinase C signaling pathways.It is a major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion.Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress. Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.
Chenodeoxycholic acid is widely utilized in therapeutic applications. It is applied in medical therapy to dissolve gallstones. It is employed in the treatment of cerebrotendineous xanthomatosis. It is used to treat constipation and cerebrotendineous xanthomatosis. It acts as a urea receptor in supramolecular chemistry which can contain anions. It is a staining additive commonly used with ruthenium or organic photo-sensitizers in the preparation of staining solutions for dye solar cells.
Chenodeoxycholic Acid is a staining additive commonly used with ruthenium or organic photo-sensitizers in the preparation of staining solutions for Dye Solar Cells. This co-adsorbent will prevent dye aggregation on the semiconductor surface, reducing losses in the solar cell's operation.
Chenodeoxycholic Acid is a white solid added with the dye powder to the solvent while preparing staining solutions. The concentration of co-adsorbent is typically 10 fold the dye concentration.
Chenodeoxycholic acid has been used in a study to assess its effects as a long-term replacement therapy for cerebrotendinous xanthomatosis (CTX).
It has also been used in a study to investigate its effects on the small-intestinal absorption of bile acids in patients with ileostomies.
Chenodeoxycholic acid (CDCA) is a hydrophobic primary bile acid that activates nuclear receptors involved in cholesterol metabolism.EC50 concentrations for activation of FXR range from 13-34 μM.In cells, CDCA also binds to bile acid binding proteins (BABP) with a reported stoichiometry of 1:2.CDCA toxicity is linked to increased cellular glutathione levels and increased oxidative stress. Exposure of cells to excess CDCA contributes to liver and intestinal cancers.